The purposes of this research were to: 1) study the level of Ministry of Education safety center policies, 2) study the level of development of drug-free schools, 3) study the relationship between the Ministry of Education safety center policies and the development of drug-free schools, and 4) create the equations of the Ministry of Education safety center policies affecting the development of drug-free schools under Sakaeo Primary Educational Service Area Office 1. This was quantitative research. The research sample was a group of 310 teachers under Sakaeo Primary Educational Service Area Office 1 in the academic year 2021. The sample size was determined using Krejcie and Morgan’s table, and proportional stratified random sampling was used based on the type of the schools. The research instrument was a 5-rating scale questionnaire which was divided into 2 parts: part 1 was about the Ministry of Education safety center policies with a reliability value of 0.85, and part 2 was about the development of drug-free schools with a reliability value of 0.85. The statistics used for data analysis were: mean, standard deviation, Pearson’s correlation coefficient and multiple regression analysis.