Although currently, the epidemic of drugs in schools is not as severe as in the past, preventive operations and problem solving of drugs in the schools must proceed continuously in order for academic places to be drug frec. Therefore, the researcher aimed at studying the preventive operations and problem solving against drugs in the schools under the Office of Vocational Education Commission, Srakaew province with the objectives to study and compare the preventive operations and solving against drugs in the schools under the Office of Vocational Education Commission, Srakaew province classified according to gender, status and school. The sample was a group of 171 teachers and educational personnel in the schools under the Office of Vocational Education Commission, Srakaew province. The sample size was calculate using Krejcie and Morgan’s comparison table. The research instrument was a five-level rating scale questionnaire with a reliability of 0.93. The statistics used for data analysis were : percentage, mean, standard deviation, T-test and One-way ANOVA.