The aims of this research were 1) to study the business adaptation of gems and jewelry entrepreneurs in the opinion of gems and jewelry association members in Chanthaburi Province and 2) compare the business adaptation of gems and jewelry entrepreneurs by gender, age, education, marital status, monthly family income, and work experience in the gems and jewelry business. The 188 entrepreneurs registered as members of gems and jewelry association with Office of Commercial Affairs Chanthaburi Province were chosen as a research sample group. The questionnaire with the three and five rating scale with the reliability level of 0.89 was used as a research tool. The statistical analyses were percentage, mean, standard deviation, t-test, F-test and Scheffe test.