The objectives of this research were to: 1) study the chronic kidney disease situation in Chanthaburi Province, 2) develop an integrated model for delaying kidney failure among these patients, and 3) evaluate the effectiveness of the model. This research was transdisciplinary and used the mixed-method design. The historical database of 6,664 medical records of chronic kidney disease patients in Chanthaburi Province was analyzed for this study, and the participants consisted of: 3 experts in the field of alternative medical treatment for delaying kidney failure, 3 experts in the field of nephrology, 3 experts in the field of the participatory process and 30 chronic kidney disease patients. The research instruments used in this study were: the medical records of the participants, a set of guidelines for the in-depth interviews, demographic questionnaires, a new medical records form specifically designed by the researcher for this study, and the World Health Organization Quality of Life (WHOQOL) assessment. The qualitative data were analyzed by content analysis, and the quantitative data were analyzed by descriptive statistics and paired t-test.